Calliope Tsoupaki was born in Piraeus, Greece, in May, 1963. Her initial studies were in piano and music theory at the Hellinicon Conservatory in Athens. Her first composition teacher in Athens was Yannis Ioannithis. Later, she studied with Louis Andriessen at the Royal Conservatory in The Hague, where she graduated in December, 1992.

Ms. Tsoupaki's works have been performed in Europe and in the United States, and she has participated in various music festivals such as Festival New Music in Middelburg in 1990 and 1992, Gaudeamus International Music Week in Amsterdam in 1991 and 1993 and several others. In 1993, she won a three-month residency from the fondation Pepinieres for young artists, to live and work in Budapest. Presently, she lives and works in Amsterdam.